Close
20/07/2018
Molecular mimicry does not mislead ALBA!
Many intracellular pathogens use molecular mimicry to ensure their survival. A part of a protein of the pathogen resembles another protein totally different from the host and many intracellular microorganisms use this capability to interfere in cellular processes that enable their survival and replication.

Researchers from the CIC bioGUNE in the Basque Country in collaboration with other groups from the United States have carried out experiments at the XALOC beamline of the ALBA Synchrotron and I04 beamline of Diamond Light Source (UK). The results enabled scientists to solve the structure of RavN, a protein of the Legionella pneumophila bacteria that uses this molecular mimicry to trick the infected cell.

Researchers have showed that the structure of RavN has a certain structural similarity with E3 eukaryotes (a set of enzymes) despite its different composition. This result allows making progress in the understanding of the molecular mechanisms active in Legionnaires' disease that can transform into pneumonia and kill infected people.
 
Article: Yi-Han Lin et al. in PLOS Pathogen

More news

09/12/2014 ADAM involved in the project of shared DC between Malaysia and Catalonia 02/12/2014 ESADE, 4th best business school in Europe 25/11/2014 Nanoparticle technology triples the production of biogas 13/11/2014 A little piece of SENER on comet 67P 05/11/2014 New catalysts investigated with the ALBA Synchrotron 04/11/2014 SENER hosts a meeting with ESA, NASA and ROSKOSMOS in its offices in BSP
36 37 38 39 40 41 42 43 44 45 46